Bioinformatic Analysis of CPEB3 in Head and Neck Squamous Cell Carcinoma via mTOR Pathway and its microRNA Targets

Objectives: To analyse CPEB3 using bioinformatic tools in several types of cancer, various HNSCC cell lines based on cancer stages, tumour grades and the gene interaction, protein regulating pathway, microRNA survival analysis. Methods: Bioinformatics used were UALCAN, TCGA, NCBI, GEPIA, Oncomine, cBioPortal, Human Protein Atlas, STRING, Metascape, miRNA Target Prediction Database. Findings: expression was considerably reduced 520 samples. Given that downregulated with pathological grading grade 1 (n=62), 2 (n=303), 3 (n=125) all 4 stages HNSCC, this suggests may be useful for determining prognosis HNSCC. interaction revealed high related proteins. causes negative regulation cytoplasmic translation, cellular response to amino acid stimulus downregulation population proliferation. Significant low patient p=0.013(p<0.05). lower patients an altered mTOR pathway relative healthy controls. miRDB results showed miR- 184-5p miR-21-5p regulate corresponding target scores 98 92. Novelty: This study is first its kind utilise analysis role biological processes. Although there are silico studies has involved molecular processes impact Further knockout warranted consider as a potential or biomarker Keywords: CPEB; HNSCC; mTOR; microRNA; insilico;